Neuropathicpain相关论文
目的:观察重复经颅直流电刺激治疗大鼠神经病理性疼痛的效果并初步探索其作用机制。方法:成年雄性SD大鼠40只，随机选取10只大鼠纳入......
目的:研究脊髓损伤患者并发神经病理性疼痛(NP)的相关危险因素。方法:回顾性分析2018年1月至2021年12月由空军军医大学第一附属医......
Central nervous system stimulation therapies in phantom limb pain: a systematic review of clinical t
Phantom limb pain is a chronic pain syndrome that is difficult to cope with. Despite neurostimulation treatment is indic......
Effects of Electroacupuncture Intervention on Expression of Cyclooxygenase 2 and Microglia in Spinal
Objective:To investigate the effect of electroacupuncture (EA) treatment on the expression of cydooxygenase (COX) 2 and ......
Increased EZH2 Levels in Anterior Cingulate Cortex Microglia Aggravate Neuropathic Pain by Inhibitin
After brachial plexus avulsion (BPA),microglia induce inflammation,initiating and maintaining neuropathic pain.EZH2 (enh......
Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Devel
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Chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons,......
Injury to peripheral nerves can lead to neuropathic pain,along with well-studied effects on sensory neurons,including hy......
Increased CXCL13 and CXCR5 in Anterior Cingulate Cortex Contributes to Neuropathic Pain-Related Cond
Pain consists of sensory-discriminative and emotional-affective components.The anterior cingulate cortex (ACC) is a crit......
Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Spec
Voltage-gated sodium channels (Navs) play an important role in human pain sensation.However,the expression and role of N......
Gait Assessment of Pain and Analgesics: Comparison of the DigiGaitTM and CatWalkTM Gait Imaging Syst
Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors.Recent studies h......
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FTY720 (fingolimod) is, after its phosphorylation by sphingosine kinase (SPHK) 2, a potent, non-selective sphingosine-1-......
A clinical study of the combination of pregabalin and celecoxib on postoperative neuropathic pain af
Objective: This study investigates the efficacy of the association of pregabalin and celecoxib on postoperative neuropat......
Objectives: Lumbar nerve root entrapment(LNRE)is one the most representative presentations for patients with lumbar disk......
A comparison of surgical invasions for spinal nerve ligation with or without paraspinal muscle remov
Introduction:L5 spinal nerve ligation (SNL) in rats is one of the most popular models for studying neuropathic pain beca......
Bulleyaconitine A blocks voltage-gated sodium channels in dorsal root ganglion neuron and attenuates
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IL-17 may contribute to central sensitization by promoting the proliferation of astrocytes and secre
Central sensitiztion has been applied to explain neuropathic pain, although its mechanism has not been well known.Intens......
Differential regulation of GSK3β in spinal dorsal horn and in hippocampus contributes to neuropathic
Objective Glycogen synthase kinase 3β(GSK3β)inhibitor is proposed as an attractive candidate for the treatment of cogn......
Spinal IL-33/ST2 signaling contributes to acute inflammatory,chronic neuropathic and cancer pain via
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GABAB receptors are involved in ventrolateral orbital cortex-evoked antinociception in rats with neu
Objective Previous studies have shown that the ventrolateral orbital cortex (VLO) is part of the endogenous analgesic sy......
GRP151 demethylation and increased interaction with STAT3 contribute to the pathogenesis of neuropat
G protein-coupled receptors(GPCRs)play important roles in the development and maintenance of chronic pain.Recent studies......
Demethylation of Cxcr3 gene promoter and upregulation of CXCL10 after spinal nerve ligation contribu
DNA methylation has been implicated in the pathogenesis of chronic pain.Here we investigated how chemokine receptor CXCR......
Clerodendron bungei steud relieves pain hypersensitivity and its possible mechanisms in rats with ne
Aim: There are studies demonstrated that neuroimmune system was involved in the generation of neuropathic pain, cytokine......
Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing
Aim: In this study we investigated anti-nociceptive effects of oxymatrine through regulation of NR2B-containing NMDA rec......
Aim: Spinal glias, including astrocytes and microglias, play an important role in neuropathic pain.Aquaporin 4 (AQP4), t......
Depression attenuated allodynia of rat with nerupathic pain via spinal dorsal horn glucucorticoid re
Nowadays,there are still many arguments on the impact of depression on pain sensory.Our previous study improved that dep......
The role of T-type Ca2+ channel in membrane potential oscillations of injured rat dorsal root gangli
The purpose of the study is investigating the role of T-type Ca2+ channel in injured DRG neurons oscillations and resona......
The glutamate transporter-1 (GLT-1) exclusively expressed on the astrocytes which functions as a glutamate scavenger pro......
The Effect of Ultrasound-Guided Percutaneous Ozone Injection Around Cervical Dorsal Root Ganglion in
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HCN Channels in the Anterior Cingulate Cortex Contribute to Neuronal Hyperexcitability of Neuropathi
Objective The anterior cingulate cortex(ACC) is a key cortical region that playscritical roles in neuropathic pain.Abnor......
Objective The red nucleus(RN) is an important nucleus of extracorticospinal tract,which comprises a critical subcortical......
Objective Vincristine(VCR),a first line antineoplastic agent,often induces neuropathic pain,and currently no means is av......
Objective Chemotherapic drugs commonly induced peripheral neuropathic pain and limited its use in clinic.Fucoidan is an ......
Upregulation of chemokine CXCL12 in the dorsal root ganglia and spinal cord contributes to the devel
Objective: Emerging evidence indicates that CXCL12/CXCR4 signaling is involved in chronic pain.However,few studies have ......
Neuropathic pain affected P2X3 receptor expression and function in DRG neurons of neonatal and adult
Nervous system of the neonatal is characterized by greater plasticity and reorganization,therefore,is particularly susce......
Liver X receptors(LXRs)are ligand activated transcription factors that belong to the nuclear receptor superfamily.LXRs p......
Hyperbaric oxygen treatment at various stages following chronic constriction injury produces differe
This study aims to investigate the effect of hyperbaric oxygen (HBO)treatment at various stages following chronic constr......
Objective Neuropathic pain, often caused by nerve injury, is commonly observed among patients with different diseases.Be......
Neuropathic pain is one of the most widespread and intractable of human complaints.Neuroinflammation is recognized to pl......
Significance of alpha smooth muscle actin expression in traumatic painful neuromas: a pilot study in
Background: Treatment of traumatic painful neuromas remains a challenge despite advances in surgical options and the mec......
Spiders are traditional medicine used for the treatment of chronic pain,but the molecular mechanism involved is not clea......
Cytokines and NF-κB signaling pathway mediated the analgesic effect of CBS on spared nerve injury mo
Neuropathic pain is a common chronic intractable pain.The current existing pharmacological treatment alternatives to all......
Introduction: Pain has been the fifth vital sign in clinical care,and pain management is an important need in clinical q......
Possible contribution of K+-Cl-cotransporter 2 down-regulation in the ventral posterior nucleus of t
Neuropathic pain is difficult to treat in clinic because of insufficient understandings of its mechanisms.Except for per......
Induction of spinal GluN2B-dependent LTP via BDNF contributes to the development of neuropathic pain
In previous studies,we have found that the GluN2B-containing NMDA(NMDA-GluN2B)receptors-mediated long-term potentiation(......
Discovery of a potent and orally-available D-amino acid oxidase inhibitor for the management of chro
Aim: It has been shown that spinal D-amino acid oxidase (DAAO) might be a potential molecular target for the treatment o......
OBJECTIVE The participation of N-type voltage-de pendence calcium channel (N-VDCC) in pain transmission has been proved,......
